Red Clover and Arterial Stiffness Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women.
Article Summary: This is a review on the study that addresses the vascular effects
of isolated red clover isoflavone. A randomized, double-blind trial
was designed. A total of 80 healthy participants, 46 were men, and
34 were women, 45 to 75 years of age. All participants were given
isoflavones enriched in either biochanin or formononetin crossed
over randomly with placebo in two 6-week periods. The end points
were measured at baseline and after each intervention which included
large artery stiffness, endothelial function in conduit arteries,
24-hour ambulatory blood pressure, and total peripheral resistance.
The study showed that the isoflavone intervention significantly
reduced arterial stiffness with improved systemic arterial compliance,
led to a reduction in total peripheral resistance and a corresponding
reduction in central pulse wave velocity compared with placebo.
There was no effect found on blood pressure or flow-mediated vasodilation.
The study concluded |
that red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance in normotensive men and postmenopausal women but with no effect on blood pressure. Authors: Insititution: Country of Publication: Source:
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