Red Clover and Bone Density

The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial.

Article Summary:

This is a review on the study that determines the effectiveness of a red clover-derived isoflavone supplement on bone density. There were 205 women aged from 49 to 65 participated in a double-blind, randomized, placebo-controlled trial. Out of the 205, 177 completed the trial. Bone density, body composition, bone turnover markers, and diet were measured at baseline and 12 months later. The results showed that loss of lumbar spine bone mineral content and bone mineral density were lower in the group with isoflavone supplement. No significant treatment effects on hip bone mineral content or bone mineral density were found. The data suggested that isoflavones have a potentially protective effect on the lumbar spine in women.

Authors:

Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA.

Insititution:

MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom.

Country of Publication:

United Kingdom

Source:

American Journal of Clinical Nutrition. 79(2):326-33, 2004 February. NIH

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