Soy
Isoflavones and Menopause
Article Summary:
This study examined the effects of different dosages of either oral
or transdermal soy isoflavones on postmenopausal women's neurovegetative
symptoms. Sixty women participated in the study, and each was randomly
assigned to one of four groups. Groups A and B were administered
50 mg or 75 mg of oral soy isoflavones per day. Groups C and D were
administered 6 mg or 12 mg of transdermal isoflavones per day. Fifteen
women were used as a control group and did not receive any supplementation
of the isoflavones. Before the study the women's hot flushes, Kupperman
index and vaginal dryness were evaluated, and these measurements
were repeated after weeks 5, 9 and 13. Groups A, B and D experienced
a reduced number of hot flushes, group D being due to the dosage
amount. After measurements at week 13, all groups, except for the
control group, were found to have a significantly decreased Kupperman
index and
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hot
flush score. Group B was the only group that experienced a reduced
vaginal dryness score. With the results from this study, we can
conclude that both oral and transdermal soy isoflavones are effective
in reducing neurovegetative symptoms in menopausal women, with the
dosage amount playing a role in the effects.
Authors:
Colacurci N, Zarcone R, Borrelli A, De Franciscis P, Fortunato N,
Cirillo M, Fornaro F.
Institution:
Department of Gynecology and Obstetrics Outpatient, Menopausal Clinic,
Second University of Naples, Naples, Italy.
Country of Publication:
Italy
Source:
Minerva Ginecol. 2004 Oct;56(5):407-12. NIH
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