Soymilk
and Bone Loss
Article Summary:
The study compares the effects of soymilk with and without isoflavones
to natural transdermal progesterone on bone mineral density of the
lumbar spine and hop. All subjects of the study were caucasian,
postmenopausal women whom have had osteoporosis or whom have atleast
three risk factors for osteoporosis. These women were randomly assigned
to four groups. Group 1 consisted of 23 women who were administered
soymilk containing 76 mg isoflavones. Group 2 consisted of 22 women
who were given transdermal progesterone. Group 3 consisted of 22
women who were given both soymilk containing isoflavones and transdermal
progesterone. Lastly, group 4 consisted of a placebo group of 22
women who were given soymilk without isoflavones and progesterone-free
cream. Before the study all women's bone mineral content and bone
mineral density were measured in lumbar spine and hip.
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These
measurments were then repeated after 2 years of the administered
treatments. After the 2 years had passed, the control group 4 and
the combination group 3 experienced significant bone loss. Groups
1 and 2 experienced unchanged bone mineral density and bone mineral
content in lumbar spine. The study concluded that taking two glasses
of soymilk containing 76 mg isoflavones daily prevents lumbar spine
bone loss in postmenopausal women, while the combination of soy
isoflavones and progesterone actually has a negative effect on bone
mineral content and density.
Authors:
Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T.
Institution:
Institute for Optimum Nutrition, Teglgaardstraede 4, 1st. floor,
1452, Copenhagen K, Denmark.
Country of Publication:
Denmark
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Source:
Eur J Nutr. 2004 Aug;43(4):246-57. Epub 2004 Apr 14. NIH
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